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The new approach offers scientists far greater control over the three-dimensional structure of a key class of molecular compounds, making it easier to fashion drug molecules that fit their targets in the right way. Two heads causes a key feature in the elbows. Pfizer's Viagra campaign consistently violated five principles, partially complied with one principle, and fully complied with two principles. The double-patenting issue in the tadalafil (CIALIS) cases concerns two of Lilly’s patents. On Nov. 01, 2017, the England and Wales Court of Appeal issued a decision in CIALIS (tadalafil) case & found that the patent for treatment of male erectile dysfunction is invalid for obviousness. 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